Comparing Risk Factors for Mild Cognitive Impairment and Alzheimer's Disease
Between Hispanic and Non-Hispanic White Subjects 
   Lead Investigator:    Cally Xiao
   Institution      :    University of Southern California
   E-Mail           :    cally.xiao@loni.usc.edu
   Proposal ID      :    1649



   Proposal Description:
   Hispanic subjects have been found to have a higher risk for developing mild cognitive impairment (MCI) and Alzheimer?s disease (AD) compared to non  Hispanic white (NHW) subjects. However, a preliminary analysis showed that having one or two copies of the APOEe4 allele is more of a risk factor for NHW subjects than for Hispanic subjects. We want to see if this trend holds true in a meta-analysis study that includes data from NACC, and determine if the higher risk for Hispanic subjects to develop MCI or AD is due to other risk factors or socioeconomic reasons. The objective of this study is to determine how different risk factors (APOE genotype, cardiovascular risk factors, demographics) contribute to disease outcome between Hispanic and NHW subjects, the results of which may inform future clinical practice.